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Shen H , Wu N , Nanayakkara G , Fu H , Yang Q , Yang WY , Li A , Sun Y , Drummer Iv C , Johnson C , Shao Y , Wang L , Xu K , Hu W , Chan M , Tam V , Choi ET , Wang H , Yang X
Co-signaling receptors regulate T-cell plasticity and immune tolerance
Front Biosci (Landmark Ed). 2019 Jan 1;24 :96-132
PMID: 30468648    PMCID: PMC6309335   
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We took an experimental database mining analysis to determine the expression of 28 co-signaling receptors in 32 human tissues in physiological/pathological conditions. We made the following significant findings: 1) co-signaling receptors are differentially expressed in tissues; 2) heart, trachea, kidney, mammary gland and muscle express co-signaling receptors that mediate CD4(+)T cell functions such as priming, differentiation, effector, and memory; 3) urinary tumor, germ cell tumor, leukemia and chondrosarcoma express high levels of co-signaling receptors for T cell activation; 4) expression of inflammasome components are correlated with the expression of co-signaling receptors; 5) CD40, SLAM, CD80 are differentially expressed in leukocytes from patients with trauma, bacterial infections, polarized macrophages and in activated endothelial cells; 6) forward and reverse signaling of 50% co-inhibition receptors are upregulated in endothelial cells during inflammation; and 7) STAT1 deficiency in T cells upregulates MHC class II and co-stimulation receptors. Our results have provided novel insights into co-signaling receptors as physiological regulators and potentiate identification of new therapeutic targets for the treatment of sterile inflammatory disorders.
1093-4715 Shen, Haitao Wu, Na Nanayakkara, Gayani Fu, Hangfei Yang, Qian Yang, William Y Li, Angus Sun, Yu Drummer Iv, Charles Johnson, Candice Shao, Ying Wang, Luqiao Xu, Keman Hu, Wenhui Chan, Marion Tam, Vincent Choi, Eric T Wang, Hong Yang, Xiaofeng R01 DK113775/DK/NIDDK NIH HHS/United States R01 HL132399/HL/NHLBI NIH HHS/United States R01 HL138749/HL/NHLBI NIH HHS/United States Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't United States Front Biosci (Landmark Ed). 2019 Jan 1;24:96-132.