FCCC LOGO Faculty Publications
Chen M , Fan L , Zhang SM , Li Y , Chen P , Peng X , Liu DB , Ma C , Zhang WJ , Zou ZW , Li PD
LINC01939 inhibits the metastasis of gastric cancer by acting as a molecular sponge of miR-17-5p to regulate EGR2 expression
Cell Death Dis. 2019 Jan 25;10(2) :70
PMID: 30683847    PMCID: PMC6347617    URL: https://www.ncbi.nlm.nih.gov/pubmed/30683847
Back to previous list
Abstract
Accumulating evidence have suggested that long noncoding RNAs (lncRNAs) are known to regulate diverse tumorigenic processes. Recently, a novel lncRNA LINC01939 was underexpressed and emerged as a tumor suppressive lncRNA in gastric cancer (GC). In this study, we aimed to investigate the biological function and molecular mechanism of LINC01939 in GC. We found that LINC01939 expression was significantly downregulated in GC tissues and cell lines. Low expression of LINC01939 was correlated with tumor metastasis and shorter survival in GC patients. Functionally, LINC01939 overexpression remarkably inhibited the invasion and migration of GC cells in vitro and in vivo. Mechanistically, LINC01939 regulated the expression of early growth response 2 (EGR2) protein by competitively binding to miR-17-5p. Upregulation of miR-17-5p reversed GC metastasis and EMT process caused by LINC01939 by rescue analysis. Taken together, these results suggested that LINC01939 repressed GC invasion and migration by functioning as a ceRNA for miR-17-5p to regulate EGR2 expression. Our findings provided a novel prognostic marker and therapeutic target for GC patients.
Notes
2041-4889 Chen, Mi Fan, Li Zhang, Si-Min Li, Yong ORCID: http://orcid.org/0000-0001-8265-577X Chen, Peng Peng, Xin Liu, Dong-Bo Ma, Charlie ORCID: http://orcid.org/0000-0002-5341-4827 Zhang, Wen-Jie Zou, Zhen-Wei Li, Pin-Dong 2016CFB374/Natural Science Foundation of Hubei Province (Hubei Provincial Natural Science Foundation) 2017CFB246/Natural Science Foundation of Hubei Province (Hubei Provincial Natural Science Foundation) 81502697/National Natural Science Foundation of China (National Science Foundation of China) 81702767/National Natural Science Foundation of China (National Science Foundation of China) 81874232/National Natural Science Foundation of China (National Science Foundation of China) Journal Article England Cell Death Dis. 2019 Jan 25;10(2):70. doi: 10.1038/s41419-019-1344-4.