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Fragoso MF , Romualdo GR , Vanderveer LA , Franco-Barraza J , Cukierman E , Clapper ML , Carvalho RF , Barbisan LF
Lyophilized acai pulp (Euterpe oleracea Mart) attenuates colitis-associated colon carcinogenesis while its main anthocyanin has the potential to affect the motility of colon cancer cells
Food Chem Toxicol. 2018 Nov;121 :237-245
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Abstract
This study evaluated the possible protective effects of lyophilized acai pulp (AP) in a colitis-associated carcinogenesis (CAC) rat model and the modifying effect of cyanidin 3-rutinoside (C3R) on the motility of RKO colon adenocarcinoma cells, using the wound healing assay. Male Wistar rats were induced to develop CAC using 1,2-dimethylhydrazine (DMH) and 2,4,6-trinitrobenzene acid (TNBS). Animals were randomly assigned to different groups that received basal diet or basal diet supplemented with 5.0% or 7.5% lyophilized AP. The findings indicate: 1) C3R (25muM) has the potential to reduce RKO cell motility in vitro; 2) ingestion of lyophilized AP reduces the total number of aberrant crypt foci (ACF), ACF multiplicity, tumor cell proliferation and incidence of tumors with high grade dysplasia; 3) AP increases the gene expression of negative regulators of cell proliferation such as Dlc1 and Akt3, as well as inflammation (Ppara). Thus, lyophilized AP could exert a potential antitumor activity.
Notes
1873-6351 Fragoso, Mariana F Romualdo, Guilherme R Vanderveer, Lisa A Franco-Barraza, Janusz Cukierman, Edna Clapper, Margie L Carvalho, Robson F Barbisan, Luis F Journal Article England Food Chem Toxicol. 2018 Sep 6;121:237-245. doi: 10.1016/j.fct.2018.08.078.