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Aldaz CM , Yeung RS , Latif F , Lerman MI , Xiao G , Trono D , Walker CL
Colocalization of the Rat Homolog of the Vonhippel-Lindau (Vhl) Gene and the Plasma-Membrane Ca++ Transporting Atpase-Isoform-2 (Atp2b2) Gene to Rat Chromosome Bands 4q41.3- 42.1
Cytogenetics and Cell Genetics. 1995 ;71(3) :253-256
AbstractUsing fluorescence in situ hybridization, we localized the rat homolog of the von Hippel-Lindau gene (Vhl) to rat chromosome band 4q41.3-->q42.1. We also mapped the gene encoding the plasma membrane Ca++-transporting ATPase isoform 2 (Atp2b2) to the same chromosome subregion. These two genes together with Raf1 appear to be members of a large syntenic gene cluster that maps to human chromosome bands 3p25 --> p26, mouse chromosome bands 6 C3 --> E, and rat chromosome bands 4q41 --> q42. Cytogenetic analysis of NRK 52E cells derived from immortalized normal rat kidney epithelial cells revealed an inverted duplication of the region containing this gene cluster.
NotesTimes Cited: 4 Article TD385 CYTOGENET CELL GENET