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Santucci-Pereira J , Pogash TJ , Patel A , Hundal N , Barton M , Camoirano A , Micale RT , La Maestra S , Balansky R , De Flora S , Russo J
Aspirin Abrogates Impairment of Mammary Gland Differentiation induced by Early in Life Second-hand Smoke in Mice
Carcinogenesis. 2018 May 17
PMID: 29788174 PMCID: PMC6067120 URL: https://www.ncbi.nlm.nih.gov/pubmed/29788174
AbstractEpidemiological studies show that there is limited evidence that tobacco smoking causes breast cancer in humans. In rodents, many tobacco smoke chemicals cause mammary gland tumors. This study evaluated the mammary gland differentiation in mice exposed to environmental cigarette smoke (ECS), using 3R4F Kentucky reference cigarettes, starting after birth and continuing daily for 10 weeks (total particulate exposure 95 mg/m3; CO 610 ppm). We also analyzed the effects of oral administration of nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin (1600mg/kg) or naproxen (320mg/kg), on mammary gland differentiation, either in unexposed or ECS-exposed mice. The ECS exposure caused delay of mammary glands development. We speculate that this delay may result from aryl hydrocarbon receptor (AHR) signaling activation, which has an antiestrogenic effect and crosstalk to the estrogen metabolism pathway. Similarly, naproxen impaired gland differentiation in unexposed and ECS-exposed mice, while aspirin hindered its development only in unexposed mice. The lack of differentiation induced by the NSAIDs could be explained by their antiestrogenic effect through inhibition of aldo-keto reductases. In ECS-exposed animals, aspirin induced intense lobular formation, which could indicate that aspirin is counteracting the AHR signaling induced by ECS. Based on the differentiation induced by aspirin in ECS-exposed animals, we postulate that these mice would be less susceptible to mammary carcinogenesis. Our results suggest that exposure to smoke at an early age impairs the development of the mammary gland, thus resulting in a longer period of susceptibility and increased risk of breast cancer. However, addition of aspirin can abrogate this effect.
Notes1460-2180 Santucci-Pereira, Julia Pogash, Thomas J Patel, Aman Hundal, Navroop Barton, Maria Camoirano, Anna Micale, Rosanna T La Maestra, Sebastiano Balansky, Roumen De Flora, Silvio Russo, Jose Journal Article England Carcinogenesis. 2018 May 17. pii: 4998815. doi: 10.1093/carcin/bgy064.