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Lindsay T , Movva S
Role of Molecular Profiling in Soft Tissue Sarcoma
J Natl Compr Canc Netw. 2018 May;16(5) :564-571
PMID: 29752329 URL: https://www.ncbi.nlm.nih.gov/pubmed/29752329
AbstractDiagnosis and treatment of soft tissue sarcoma (STS) is a particularly daunting task, largely due to the profound heterogeneity that characterizes these malignancies. Molecular profiling has emerged as a useful tool to confirm histologic diagnoses and more accurately classify these malignancies. Recent large-scale, multiplatform analyses have begun the work of establishing a more complete understanding of molecular profiling in STS subtypes and to identify new molecular alterations that may guide the development of novel targeted therapies. This review provides a brief and general overview of the role that molecular profiling has in STS, highlighting select sarcoma subtypes that are notable for recent developments. The role of molecular profiling as it relates to diagnostic strategies is discussed, along with ways that molecular profiling may provide guidance for potential therapeutic interventions.
Notes1540-1413 Lindsay, Timothy Movva, Sujana Journal Article Review United States J Natl Compr Canc Netw. 2018 May;16(5):564-571. doi: 10.6004/jnccn.2018.7015.