FCCC LOGO Faculty Publications
Zou ZW , Liu T , Li Y , Chen P , Peng X , Ma C , Zhang WJ , Li PD
Melatonin suppresses thyroid cancer growth and overcomes radioresistance via inhibition of p65 phosphorylation and induction of ROS
Redox Biol. 2018 Mar 1;16 :226-236
PMID: 29525603    PMCID: PMC5854931   
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Abstract
Thyroid cancer is the most common endocrine carcinoma with increasing incidence worldwide and anaplastic subtypes are frequently associated with cancer related death. Radioresistance of thyroid cancer often leads to therapy failure and cancer-related death. In this study, we found that melatonin showed potent suppressive roles on NF-kappaB signaling via inhibition of p65 phosphorylation and generated redox stress in thyroid cancer including the anaplastic subtypes. Our data showed that melatonin significantly decreased cell viability, suppressed cell migration and induced apoptosis in thyroid cancer cell lines in vitro and impaired tumor growth in the subcutaneous mouse model in vivo. By contrast, irradiation of thyroid cancer cells resulted in elevated level of phosphorylated p65, which could be reversed by cotreatment with melatonin. Consequently, melatonin synergized with irradiation to induce cytotoxicity to thyroid cancer, especially in the undifferentiated subgroups. Taken together, our results suggest that melatonin may exert anti-tumor activities against thyroid carcinoma by inhibition of p65 phosphorylation and induction of reactive oxygen species. Radio-sensitization by melatonin may have clinical benefits in thyroid cancer.
Notes
2213-2317 Zou, Zhen-Wei Liu, Ting Li, Yong Chen, Peng Peng, Xin Ma, Charlie Zhang, Wen-Jie Li, Pin-Dong Journal Article Netherlands Redox Biol. 2018 Mar 1;16:226-236. doi: 10.1016/j.redox.2018.02.025.