This is an archive of papers published by the staff and faculty of Fox Chase Cancer Center. For questions about content, please contact Talbot Research Library
Last updated on
Qumseya BJ , Bartel MJ , Gendy S , Bain P , Qumseya A , Wolfsen H
High rate of over-staging of Barrett's neoplasia with endoscopic ultrasound: Systemic review and meta-analysis
Dig Liver Dis. 2018 May;50(5) :438-445
PMID: 29573963 URL: https://www.ncbi.nlm.nih.gov/pubmed/29573963
AbstractBACKGROUND: The use of endoscopic ultrasound (EUS) to stage patients with Barrett's esophagus (BE) with suspected neoplasia is controversial due to high rates of over-staging. However, this rate of over-staging has not been adequately investigated or quantified. AIM: To determine the rate of over-staging related EUS in this population. METHODS: Search included Medline, Embase, Web of Science, and Cochrane Central ending on 9/30/2016. The primary effect-estimate of interest was the false positive rate of advanced disease on EUS at the tumor level (T1a vs. T1b). Secondary outcomes included false detection rate, false negative rate, accuracy, sensitivity, and specificity. Study heterogeneity was assessed using the I2 and Cochrane's Q. RESULTS: Of 1872 studies, 11 met our inclusion criteria totaling 895 patients. Based on random effects models, the pooled FPR for advanced disease was 9.1% ([6.5-12.5%], p<0.001). Tests of heterogeneity showed no significant heterogeneity for this outcome. The pooled false negative rate was 9.2% [95%CI: 4.7-17.3%], p<0.01. Overall, the pooled accuracy of EUS results in BE neoplasia patients was low at 74.6% [58.7-85.8%], p=0.004. CONCLUSIONS: The use of EUS in BE patients with dysplasia and early neoplasia results in a large proportion of patients falsely over-staged and under-staged.
Notes1878-3562 Qumseya, Bashar J Bartel, Michael J Gendy, Sherif Bain, Paul Qumseya, Amira Wolfsen, Herbert Journal Article Review Netherlands Dig Liver Dis. 2018 Mar 1. pii: S1590-8658(18)30203-2. doi: 10.1016/j.dld.2018.02.005.