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Galluzzi L , Vitale I , Aaronson SA , Abrams JM , Adam D , Agostinis P , Alnemri ES , Altucci L , Amelio I , Andrews DW , Annicchiarico-Petruzzelli M , Antonov AV , Arama E , Baehrecke EH , Barlev NA , Bazan NG , Bernassola F , Bertrand MJM , Bianchi K , Blagosklonny MV , Blomgren K , Borner C , Boya P , Brenner C , Campanella M , Candi E , Carmona-Gutierrez D , Cecconi F , Chan FK , Chandel NS , Cheng EH , Chipuk JE , Cidlowski JA , Ciechanover A , Cohen GM , Conrad M , Cubillos-Ruiz JR , Czabotar PE , D'Angiolella V , Dawson TM , Dawson VL , De Laurenzi V , De Maria R , Debatin KM , DeBerardinis RJ , Deshmukh M , Di Daniele N , Di Virgilio F , Dixit VM , Dixon SJ , Duckett CS , Dynlacht BD , El-Deiry WS , Elrod JW , Fimia GM , Fulda S , Garcia-Saez AJ , Garg AD , Garrido C , Gavathiotis E , Golstein P , Gottlieb E , Green DR , Greene LA , Gronemeyer H , Gross A , Hajnoczky G , Hardwick JM , Harris IS , Hengartner MO , Hetz C , Ichijo H , Jaattela M , Joseph B , Jost PJ , Juin PP , Kaiser WJ , Karin M , Kaufmann T , Kepp O , Kimchi A , Kitsis RN , Klionsky DJ , Knight RA , Kumar S , Lee SW , Lemasters JJ , Levine B , Linkermann A , Lipton SA , Lockshin RA , Lopez-Otin C , Lowe SW , Luedde T , Lugli E , MacFarlane M , Madeo F , Malewicz M , Malorni W , Manic G , Marine JC , Martin SJ , Martinou JC , Medema JP , Mehlen P , Meier P , Melino S , Miao EA , Molkentin JD , Moll UM , Munoz-Pinedo C , Nagata S , Nunez G , Oberst A , Oren M , Overholtzer M , Pagano M , Panaretakis T , Pasparakis M , Penninger JM , Pereira DM , Pervaiz S , Peter ME , Piacentini M , Pinton P , Prehn JHM , Puthalakath H , Rabinovich GA , Rehm M , Rizzuto R , Rodrigues CMP , Rubinsztein DC , Rudel T , Ryan KM , Sayan E , Scorrano L , Shao F , Shi Y , Silke J , Simon HU , Sistigu A , Stockwell BR , Strasser A , Szabadkai G , Tait SWG , Tang D , Tavernarakis N , Thorburn A , Tsujimoto Y , Turk B , Vanden Berghe T , Vandenabeele P , Vander Heiden MG , Villunger A , Virgin HW , Vousden KH , Vucic D , Wagner EF , Walczak H , Wallach D , Wang Y , Wells JA , Wood W , Yuan J , Zakeri Z , Zhivotovsky B , Zitvogel L , Melino G , Kroemer G
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
Cell Death Differ. 2018 Mar;25(3) :486-541
PMID: 29362479    PMCID: PMC5864239    URL: https://www.ncbi.nlm.nih.gov/pubmed/29362479
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Abstract
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field.
Notes
1476-5403 Galluzzi, Lorenzo Vitale, Ilio Aaronson, Stuart A Abrams, John M Adam, Dieter Agostinis, Patrizia Alnemri, Emad S Altucci, Lucia Amelio, Ivano Andrews, David W Annicchiarico-Petruzzelli, Margherita Antonov, Alexey V Arama, Eli Baehrecke, Eric H Barlev, Nickolai A Bazan, Nicolas G Bernassola, Francesca Bertrand, Mathieu J M Bianchi, Katiuscia Blagosklonny, Mikhail V Blomgren, Klas Borner, Christoph Boya, Patricia Brenner, Catherine Campanella, Michelangelo Candi, Eleonora Carmona-Gutierrez, Didac Cecconi, Francesco Chan, Francis K-M Chandel, Navdeep S Cheng, Emily H Chipuk, Jerry E Cidlowski, John A Ciechanover, Aaron Cohen, Gerald M Conrad, Marcus Cubillos-Ruiz, Juan R Czabotar, Peter E D'Angiolella, Vincenzo Dawson, Ted M Dawson, Valina L De Laurenzi, Vincenzo De Maria, Ruggero Debatin, Klaus-Michael DeBerardinis, Ralph J Deshmukh, Mohanish Di Daniele, Nicola Di Virgilio, Francesco Dixit, Vishva M Dixon, Scott J Duckett, Colin S Dynlacht, Brian D El-Deiry, Wafik S Elrod, John W Fimia, Gian Maria Fulda, Simone Garcia-Saez, Ana J Garg, Abhishek D Garrido, Carmen Gavathiotis, Evripidis Golstein, Pierre Gottlieb, Eyal Green, Douglas R Greene, Lloyd A Gronemeyer, Hinrich Gross, Atan Hajnoczky, Gyorgy Hardwick, J Marie Harris, Isaac S Hengartner, Michael O Hetz, Claudio Ichijo, Hidenori Jaattela, Marja Joseph, Bertrand Jost, Philipp J Juin, Philippe P Kaiser, William J Karin, Michael Kaufmann, Thomas Kepp, Oliver Kimchi, Adi Kitsis, Richard N Klionsky, Daniel J Knight, Richard A Kumar, Sharad Lee, Sam W Lemasters, John J Levine, Beth Linkermann, Andreas Lipton, Stuart A Lockshin, Richard A Lopez-Otin, Carlos Lowe, Scott W Luedde, Tom Lugli, Enrico MacFarlane, Marion Madeo, Frank Malewicz, Michal Malorni, Walter Manic, Gwenola Marine, Jean-Christophe Martin, Seamus J Martinou, Jean-Claude Medema, Jan Paul Mehlen, Patrick Meier, Pascal Melino, Sonia Miao, Edward A Molkentin, Jeffery D Moll, Ute M Munoz-Pinedo, Cristina Nagata, Shigekazu Nunez, Gabriel Oberst, Andrew Oren, Moshe Overholtzer, Michael Pagano, Michele Panaretakis, Theocharis Pasparakis, Manolis Penninger, Josef M Pereira, David M Pervaiz, Shazib Peter, Marcus E Piacentini, Mauro Pinton, Paolo Prehn, Jochen H M Puthalakath, Hamsa Rabinovich, Gabriel A Rehm, Markus Rizzuto, Rosario Rodrigues, Cecilia M P Rubinsztein, David C Rudel, Thomas Ryan, Kevin M Sayan, Emre Scorrano, Luca Shao, Feng Shi, Yufang Silke, John Simon, Hans-Uwe Sistigu, Antonella Stockwell, Brent R Strasser, Andreas Szabadkai, Gyorgy Tait, Stephen W G Tang, Daolin Tavernarakis, Nektarios Thorburn, Andrew Tsujimoto, Yoshihide Turk, Boris Vanden Berghe, Tom Vandenabeele, Peter Vander Heiden, Matthew G Villunger, Andreas Virgin, Herbert W Vousden, Karen H Vucic, Domagoj Wagner, Erwin F Walczak, Henning Wallach, David Wang, Ying Wells, James A Wood, Will Yuan, Junying Zakeri, Zahra Zhivotovsky, Boris Zitvogel, Laurence Melino, Gerry Kroemer, Guido Journal Article Review England Cell Death Differ. 2018 Jan 23. pii: 10.1038/s41418-017-0012-4. doi: 10.1038/s41418-017-0012-4.