FCCC LOGO Faculty Publications
Shi X , Ba R , You H , Jiang Q , Huang J , Mao J , Han L , Zhang S , Zhuang Q , Yu X , Wang L , Wang Y , Li D , Zhu W , Zhang Y , Zhu Y , Xi X
A rare case of B-lymphoproliferative disorder with villous lymphocytes harboring t(8;14)(q24;q32) translocation
Front Med. 2018 Jun;12(3) :324-329
Back to previous list
Splenic lymphoma with villous lymphocytes (SLVL) or splenic marginal zone lymphoma with circulating villous lymphocytes is rare, and prolymphocytic transformation of SLVL is rarer. At present, only one case of SLVL with t(8;14)(q24;q32) translocation has been reported. In this study, we report a case of Blymphoproliferative disorder with villous lymphocytes harboring t(8;14)(q24;q32) chromosome translocation that we inclined to SLVL with a prolymphocytic transformation. A 73-year-old female showed marked hepatosplenomegaly and high lymphocytosis (lymphocytes > 200 x 109/L). The abnormal lymphocytes had short coarse villi and round nuclei with prominent nucleoli. The immunophenotypes showed CD19+, CD20+, HLADR+, CD22+, CD5+, Kappa+, CD25dim, CD71dim, Lambda-, CD7-, CD10-, CD23-, CD34-, CD33-, CD13-, CD14-, CD117-, CD64-, CD103-, and CD11c-. The karyotype showed complex abnormality: 46XX,+ 3,-10, t(8;14)(q24; q32)[11]/46XX[9]. The cytoplasmic projection, immunological characteristics, and trisomy 3 chromosome abnormality supported the diagnosis of SLVL. However, the presence of prominent nucleoli and high lymphocytosis suggested prolymphocytic transformation, probably as a result of t(8,14) chromosome translocation. In this report, we described an unusual case of B-lymphoproliferative disorder with villous lymphocytes harboring t(8;14)(q24;q32) translocation, which could provide help in the diagnosis and differential diagnosis of B-lymphocytic proliferative diseases.
2095-0225 Shi, Xiaofeng Ba, Rong You, Haiyan Jiang, Qian Huang, Jiansong Mao, Jianhua Han, Lanxiu Zhang, Shuo Zhuang, Qin Yu, Xianqiu Wang, Lixia Wang, Yun Li, Dongya Zhu, Wei Zhang, Yong Zhu, Yan Xi, Xiaodong Case Reports China Front Med. 2018 Jun;12(3):324-329. doi: 10.1007/s11684-017-0558-z. Epub 2017 Oct 27.