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Werlang ME , Lewis MD , Bartel MJ
Tumor Necrosis Factor Alpha Inhibitor-Induced Acute Pancreatitis
ACG Case Rep J. 2017 Aug;4 :e103
PMID: 28879208 PMCID: PMC5577046
AbstractTreatment of acute pancreatitis remains a challenge, with therapy focused on supportive care and treating the inciting etiology. Tumor necrosis factor-alpha (TNFalpha) inhibitors have shown promising results treating acute pancreatitis in animal models, but they have not been evaluated in human trials yet. A 25-year-old woman presented with ulcerative colitis. She was unresponsive to immunomodulators and developed acute pancreatitis shortly after initiation of a TNFalpha inhibitor. Her symptoms subsided after discontinuation of the medication, but reemerged when a different TNFalpha inhibitor was introduced to control her ulcerative colitis. Other potential etiologies were investigated and clinically excluded by laboratory and imaging studies.
NotesWerlang, Monia E Lewis, Michele D Bartel, Michael J Journal Article United States ACG Case Rep J. 2017 Aug 30;4:e103. doi: 10.14309/crj.2017.103. eCollection 2017.