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Rossiter SE , Fletcher MH , Wuest WM
Natural Products as Platforms To Overcome Antibiotic Resistance
Chem Rev. 2017 Oct 11;117(19) :12415-12474
PMID: 28953368    PMCID: PMC5869711    URL: https://www.ncbi.nlm.nih.gov/pubmed/28953368
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Natural products have served as powerful therapeutics against pathogenic bacteria since the golden age of antibiotics of the mid-20th century. However, the increasing frequency of antibiotic-resistant infections clearly demonstrates that new antibiotics are critical for modern medicine. Because combinatorial approaches have not yielded effective drugs, we propose that the development of new antibiotics around proven natural scaffolds is the best short-term solution to the rising crisis of antibiotic resistance. We analyze herein synthetic approaches aiming to reengineer natural products into potent antibiotics. Furthermore, we discuss approaches in modulating quorum sensing and biofilm formation as a nonlethal method, as well as narrow-spectrum pathogen-specific antibiotics, which are of interest given new insights into the implications of disrupting the microbiome.
1520-6890 Rossiter, Sean E Fletcher, Madison H Wuest, William M ORCID: http://orcid.org/0000-0002-5198-7744 Journal Article United States Chem Rev. 2017 Sep 27. doi: 10.1021/acs.chemrev.7b00283.