This is an archive of papers published by the staff and faculty of Fox Chase Cancer Center. For questions about content, please contact Talbot Research Library
Last updated on
Randomized Controlled Trials in Hereditary Cancer Syndromes
Surgical Oncology Clinics of North America. 2017 Oct;26(4) :729-750
PMID: 28923228 URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85027587745&doi=10.1016%2fj.soc.2017.05.011&partnerID=40&md5=23dfd3da2f95194c8ece80b9466b1416
AbstractConducting randomized controlled trials (RCTs) in patients with germline mutations in genes that predispose to adult-onset cancer is hampered by the rarity of these mutations, barriers to their identification, and challenges inherent to randomizing high-risk individuals as part of a clinical trial. Most of the clinically relevant RCTs have been conducted in 3 syndromes in only some of the high-risk genes for which clinical testing is currently available. This article reviews the surgical, screening, and chemoprevention RCTs in each of the syndromes in clinically relevant studies conducted in the past 10 years.
NotesExport Date: 1 September 2017 Article in Press