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Testing PARP Inhibitors Using a Murine Xenograft Model
Methods Mol Biol. 2017 ;1608 :313-320
PMID: 28695518 URL: https://www.ncbi.nlm.nih.gov/pubmed/28695518
AbstractAnimal models are indispensable research tools for various drug discovery and development applications. In cancer research, the growth of tumors in vivo is necessary in order to closely modulate a potential response in humans. Ectopic (subcutaneous) xenografting of human cancer cells into immunodeficient mice has long been the standard model for preclinical evaluation of novel antitumor therapeutic agents. Here, we describe the establishment and use of subcutaneous xenograft mouse model to evaluate the antitumor activity of PARP-1 inhibitors.
Notes1940-6029 Makhov, Peter Naito, Sei Kolenko, Vladimir M Journal Article United States Methods Mol Biol. 2017;1608:313-320. doi: 10.1007/978-1-4939-6993-7_20.