This is an archive of papers published by the staff and faculty of Fox Chase Cancer Center. For questions about content, please contact Talbot Research Library
Last updated on
London WT , Evans AA , McGlynn K , Buetow K , An P , Gao LL , Lustbader E , Ross E , Chen GC , Shen FM
Viral, host and environmental risk factors for hepatocellular carcinoma: A prospective study in Haimen City, China
Intervirology. 1995 May-Aug;38(3-4) :155-161
AbstractTo identify specific environmental, viral, and genetic risk factors for hepatocellular carcinoma (HCC) and the interaction of such factors, we are conducting a prospective study in a high-incidence area of China. Questionnaires were completed and biosamples collected by 60,984 men ages 30-64 years, at study entry. Within 2.5 years, 183 deaths from HCC had occurred. Each HCC case was matched with 5 controls and compared for items on the questionnaire. In addition to chronic hepatitis B virus (HBV) infection, the significant risk factors were: occupation (peasant), corn consumption (in the 1970s), family history of HCC, and history of an episode of acute hepatitis as an adult. HBV, consumption of aflatoxins, a genetic factor, and possibly a second hepatitis virus infection contribute to the risk of HCC.
NotesTimes Cited: 17 English Article TN729 INTERVIROLOGY