FCCC LOGO Faculty Publications
Laub PB , Gallo JM
NCOMP - A windows-based computer program for noncompartmental analysis of pharmacokinetic data
Journal of Pharmaceutical Sciences. 1996 Apr;85(4) :393-395
PMID: ISI:A1996UD66800009   
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The computer program NCOMP performs noncompartmental analysis of pharmacokinetic data obtained from iv bolus, continuous infusion, and oral modes of administration. Integration of area-under-the-curve and area-under-the-first-moment-curve is done by either Lagrange polynomials or the hybrid method of Purves, which uses parabola-through-the-origin and log trapezoidal algorithms. Written for Microsoft Windows, NCOMP is designed to be used in conjunction with a spreadsheet program for graphical display and handling of data. NCOMP interactively aids the user in determining how best to extrapolate the areas to time infinity and in estimating the time zero concentration for iv bolus data.
Times Cited: 24 English Article UD668 J PHARM SCI