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Hu JM , Seeger C
Hsp90 is required for the activity of a hepatitis B virus reverse transcriptase
Proceedings of the National Academy of Sciences of the United States of America. 1996 Feb 6;93(3) :1060-1064
AbstractThe heat shock protein Hsp90 is known as an essential component of several signal transduction pathways and has now been identified as an essential host factor for hepatitis B virus replication. Hsp90 interacts with the viral reverse transcriptase to facilitate the formation of a ribonucleoprotein (RNP) complex between the polymerase and an RNA ligand, This RNP complex is required early in replication for viral assembly and initiation of DNA synthesis through a protein-priming mechanism. These results thus invoke a role for the Hsp90 pathway in the formation of an RNP.
NotesTimes Cited: 101 English Article TU640 PROC NAT ACAD SCI USA