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Dong Y , Li T , Churilla TM , Viterbo R , Sobczak ML , Smaldone MC , Chen DY , Uzzo RG , Hallman MH , Horwitz EM
Effects of Time to Treatment on Biochemical and Clinical Outcomes for Patients With Prostate Cancer Treated With Definitive Radiation
Clin Genitourin Cancer. 2016 Oct;14(5) :e463-e468
PMID: 26935996 PMCID: PMC7646312 URL: http://www.ncbi.nlm.nih.gov/pubmed/26935996
AbstractINTRODUCTION: The purpose of this study was to evaluate if time to treatment (TTT) has an effect on outcomes for patients with localized prostate cancer treated with definitive external beam radiation therapy (EBRT). PATIENTS AND METHODS: We included 4064 patients (1549 low-risk, 1612 intermediate-risk, and 903 high-risk) treated with EBRT. For each National Comprehensive Cancer Network (NCCN) risk group, TTT (defined as the time between initial positive prostate biopsy and start of RT) was analyzed in 4 intervals: < 3, 3-6, 6-9, and 9-24 months. We recorded the use of androgen deprivation therapy among patients with intermediate-risk and high-risk disease. RESULTS: The median TTT was 3.3 months (range, 0.6-23.5 months), and it was similar for each risk group (range, 3.3-3.4 months). The median follow up was 64 months. There were no significant differences in biochemical failure, distant metastasis, or overall survival for patients with TTT < 3, 3-6, 6-9, or 9-24 months for each risk group. There were also no significant differences in the outcomes at 5 years when patients with TTT > 3.3 months were compared with those with TTT </= 3.3 months for each risk group. For high-risk men, 328 of 450 (72.9%) with TTT > 3.3 months were on androgen deprivation therapy (ADT) versus 299 of 453 (66%) with TTT </= 3.3 months. Among men with high-risk cancer treated without ADT, there remained no significant difference in outcomes between TTT > 3.3 months and TTT </= 3.3 months. CONCLUSION: TTT was not associated with significant differences in outcomes among each risk group of men with localized prostate cancer treated with EBRT. Among the high-risk patients, there were no observed detriments in outcomes with TTT > 3.3 months regardless of androgen deprivation therapy use.
NotesDong, Yanqun Li, Tianyu Churilla, Thomas M Viterbo, Rosalia Sobczak, Mark L Smaldone, Marc C Chen, David Y T Uzzo, Robert G Hallman, Mark H Horwitz, Eric M ENG 2016/03/05 06:00 Clin Genitourin Cancer. 2016 Oct;14(5):e463-e468. doi: 10.1016/j.clgc.2016.01.014. Epub 2016 Feb 10.