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Genetic testing for hereditary cancer predisposition: BRCA1/2, Lynch syndrome, and beyond
Gynecol Oncol. 2016 Mar;140(3) :565-74
PMID: 26812021    PMCID: PMC4767686    URL: http://www.ncbi.nlm.nih.gov/pubmed/26812021
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Obstetrician/gynecologists and gynecologic oncologists serve an integral role in the care of women at increased hereditary risk of cancer. Their contribution includes initial identification of high risk patients, screening procedures like bimanual exam, trans-vaginal ultrasound and endometrial biopsy, prophylaxis via TAH and/or BSO, and chemoprevention. Further, gynecologists also serve a central role in the management of the secondary repercussions of efforts to mitigate increased cancer risks, including vasomotor symptoms, sexual function, bone health, cardiovascular disease, and mental health. The past several years has seen multiple new high and moderate penetrance genes introduced into the clinical care of women at increased risk of gynecologic malignancy. Awareness of these new genes and the availability of new multi-gene panel tests is critical for providers on the front-line of women's health.
Hall, M J Obeid, E I Schwartz, S C Mantia-Smaldone, G Forman, A D Daly, M B eng P30 CA006927/CA/NCI NIH HHS/ Review 2016/01/27 06:00 Gynecol Oncol. 2016 Mar;140(3):565-74. doi: 10.1016/j.ygyno.2016.01.019. Epub 2016 Jan 23.