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Association of treatment factors with surgical outcomes in tri-modality therapy for esophageal cancer
J Surg Oncol. 2015 Nov;112(6) :629-33
PMID: 26430952 URL: http://www.ncbi.nlm.nih.gov/pubmed/26430952
AbstractBACKGROUND AND OBJECTIVES: To identify the impact of the interval between chemoradiation to surgery on morbidity and mortality in patients undergoing tri-modality therapy for esophageal cancer. METHODS: Eighty-five patients completed chemoradiation followed by esophagectomy between 2006 and 2011. The interval between completion of chemoradiation and surgery was calculated for each patient. We evaluated the association of quartiles and 3-week groups with morbidity and mortality using logistic regression. Other treatment and clinical factors were also assessed. RESULTS: A total of 59 patients(69%) experienced at least one complication. When examining specific complications, patients with pulmonary complications had a longer mean time interval from chemoradiation to surgery (P = 0.02). Linear regression showed an association between longer interval between chemoradiation to surgery and hospital length of stay (LOS) >14 days when analyzing by both interval quartile (P = 0.04) and 3-week intervals (P = 0.04). On multivariable analysis, increased time interval predicted for pulmonary complications (P < 0.01) and LOS >14 days (P = 0.03). When examining other treatment factors, squamous cell histology (P = 0.02) also predicted for a hospital length of stay >14 days. CONCLUSIONS: Factors such as interval between completion of chemoradiation and surgery and squamous cell histology may be associated with surgical morbidity. Further data is warranted to confirm these findings. J. Surg. Oncol. 2015;112:629-633. (c) 2015 Wiley Periodicals, Inc.
NotesShaikh, Talha Thomay, Alan Ruth, Karen Cohen, Steven J Meyer, Joshua E United States J Surg Oncol. 2015 Nov;112(6):629-33. doi: 10.1002/jso.24060. Epub 2015 Oct 2.