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Ciaccio PJ , Walsh ES , Tew KD
Promoter analysis of a human dihydrodiol dehydrogenase
Biochemical and Biophysical Research Communications. 1996 Nov 12;228(2) :524-529
AbstractThe 5' flanking region of a human dihydrodiol dehydrogenase (DDH) gene was isolated and sequenced from bp +124 to -1161. It contains putative binding sites for liver specific factors including NF-IL6 and HNF-5 sites and AP-1, AP-2 and NF kappa B- like sites. Sequence analysis identified this gene as a type II DDH. Reporter analysis of deletion constructs transfected in HepG2 cells identified negative regulatory regions and a minimal promoter (-104 to +65) containing two AP-2 sites in tandem. (C) 1996 Academic Press, Inc.
NotesTimes Cited: 6 English Article VT768 BIOCHEM BIOPHYS RES COMMUN