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Wiest DL
Development of gammadelta T Cells, the Special-Force Soldiers of the Immune System
Methods Mol Biol. 2016 ;1323 :23-32
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While the functions of alphabeta T cells in host resistance to pathogen infection are understood in far more detail than those of gammadelta lineage T cells, gammadelta T cells perform critical, essential functions during immune responses that cannot be compensated by alphabeta T cells. Accordingly, it is essential to understand how the development of gammadelta T cells is controlled so that their generation and function might be manipulated in future for therapeutic benefit. This introductory chapter will cover the basic processes that underlie gammadelta T cell development in the thymus, as well as the current understanding of how they are controlled.
Wiest, David L United States Methods Mol Biol. 2016;1323:23-32. doi: 10.1007/978-1-4939-2809-5_2.