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Motzer RJ , Jonasch E , Agarwal N , Beard C , Bhayani S , Bolger GB , Chang SS , Choueiri TK , Costello BA , Derweesh IH , Gupta S , Hancock SL , Kim JJ , Kuzel TM , Lam ET , Lau C , Levine EG , Lin DW , Michaelson MD , Olencki T , Pili R , Plimack ER , Rampersaud EN , Redman BG , Ryan CJ , Sheinfeld J , Shuch B , Sircar K , Somer B , Wilder RB , Dwyer M , Kumar R
Testicular Cancer, Version 2.2015
J Natl Compr Canc Netw. 2015 Jun;13(6) :772-99
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Germ cell tumors (GCTs) account for 95% of testicular cancers. Testicular GCTs constitute the most common solid tumor in men between the ages of 20 and 34 years, and the incidence of testicular GCTs has been increasing in the past 2 decades. Testicular GCTs are classified into 2 broad groups--pure seminoma and nonseminoma--which are treated differently. Pure seminomas, unlike nonseminomas, are more likely to be localized to the testis at presentation. Nonseminoma is the more clinically aggressive tumor associated with elevated serum concentrations of alphafetoprotein (AFP). The diagnosis of a seminoma is restricted to pure seminoma histology and a normal serum concentration of AFP. When both seminoma and elements of a nonseminoma are present, management follows that for a nonseminoma. The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Testicular Cancer outline the diagnosis, workup, risk assessment, treatment, and follow-up schedules for patients with both pure seminoma and nonseminoma.
Motzer, Robert J Jonasch, Eric Agarwal, Neeraj Beard, Clair Bhayani, Sam Bolger, Graeme B Chang, Sam S Choueiri, Toni K Costello, Brian A Derweesh, Ithaar H Gupta, Shilpa Hancock, Steven L Kim, Jenny J Kuzel, Timothy M Lam, Elaine T Lau, Clayton Levine, Ellis G Lin, Daniel W Michaelson, M Dror Olencki, Thomas Pili, Roberto Plimack, Elizabeth R Rampersaud, Edward N Redman, Bruce G Ryan, Charles J Sheinfeld, Joel Shuch, Brian Sircar, Kanishka Somer, Brad Wilder, Richard B Dwyer, Mary Kumar, Rashmi eng J Natl Compr Canc Netw. 2015 Jun;13(6):772-99.