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AriasMendoza F , Javaid T , Stoyanova R , Brown TR , Gonen O
Heteronuclear multivoxel spectroscopy of in vivo human brain: Two-dimensional proton interleaved with three-dimensional H-1- decoupled phosphorus chemical shift imaging
Nmr in Biomedicine. 1996 May;9(3) :105-113
PMID: ISI:A1996VK94400002   
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Multivoxel, heteronuclear interleaved two-dimensional proton and three-dimensional H-1-decoupled P-31 CSI Of human brain is demonstrated. This method offers efficient use of limited examination time as patient preparation, coil tuning, shimming and imaging are done only once and the CSI data sets from both nuclei are obtained concurrently, Effective interleaving of P- 31 and H-1 is possible due to the shorter T(1)s of proton brain metabolites, alllowing a H-1 acquisition cycle to be inserted into each P-31 TR. This way, the entire MRS time is available to both nuclei, increasing their SNR per-unit-time by similar to 12% for P-31 and similar to 80% for H-1, compared with sequential detection of equal (45-60 min) length. The spectral resolution and SNR of P-31 are further increased through bi- level H-1-decoupling and NOE.
Times Cited: 2 English Article VK944 NMR BIOMED