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Zhang W , Grivennikov SI
Top Notch cancer stem cells by paracrine NF-kappaB signaling in breast cancer
Breast Cancer Res. 2013 ;15(5) :316
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Cancer stem cells are likely to play critical roles in metastasis, therapy resistance, and recurrence of hematological and solid malignancies. It is well known that the stem cell niche plays a key role for asymmetric division and homeostasis of normal stem cells, whereas cancer stem cells seem to use these niches. Among many pathways involved in self-renewal of cancer stem cells, nuclear factor-kappa B (NF-kappaB) signaling has been documented to promote their expansion in a cell-autonomous fashion. A recent study, however, suggests that paracrine NF-kappaB activation promotes the expansion of cancer stem cells through the activation of Notch in basal-type breast cancer cells.
Zhang, Weizhou Grivennikov, Sergei I eng Comment England 2013/11/01 06:00 Breast Cancer Res. 2013;15(5):316.