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Dai X , Zhao Y , Liang Z , Dassarath M , Wang L , Jin L , Chen L , Dong J , Price RA , Ma CM
Volumetric-modulated arc therapy for oropharyngeal carcinoma: a dosimetric and delivery efficiency comparison with static-field IMRT
Phys Med. 2015 Feb;31(1) :54-9
PMID: 25284321 PMCID: PMC4282814 URL: https://www.ncbi.nlm.nih.gov/pubmed/25284321
AbstractThe purpose of this study is to evaluate the treatment plan adequacy and delivery efficiency among volumetric-modulated arc therapy (VMAT) with one or two arcs and the conventional static-field dynamic multileaf collimator (dMLC) intensity-modulated radiation therapy (IMRT) in patients undergoing oropharyngeal carcinoma. Fifteen patient cases were included in this investigation. Each of the cases was planned using step-and-shoot IMRT, VMAT with a single arc (Arc1) and VMAT with double arcs (Arc2). A two-dose level prescription for planning target volumes (PTVs) was delivered with 70 Gy/56 Gy in 30 fractions. Comparisons were performed of the dose-volume histograms (DVH) for PTVs, the DVH for organs at risk (OARs), the monitor units per fraction (MU/fx), and delivery time. IMRT and Arc2 achieved similar target coverage, but superior to Arc1. Apart from the oral cavity, Arc1 showed no advantage in sparing of OARs compared with IMRT, while Arc2 obtained equivalent or better sparing of OARs among the three techniques. VMAT reduced MU/fx and shortened delivery time remarkably compared with IMRT. Our results demonstrated that for oropharyngeal cases, Arc2 can achieve superior target coverage and normal tissue sparing, as well as a significant reduction in treatment time.
NotesDai, Xiaofang Zhao, Yingchao Liang, Zhiwen Dassarath, Meera Wang, Lu Jin, Lihui Chen, Lili Dong, James Price, Robert A Ma, C-M eng P30 CA006927/CA/NCI NIH HHS/ Comparative Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Italy Phys Med. 2015 Feb;31(1):54-9. doi: 10.1016/j.ejmp.2014.09.003. Epub 2014 Oct 3.