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Kalbasi A , Swisher-McClure S , Mitra N , Sunderland R , Smaldone MC , Uzzo RG , Bekelman JE
Low rates of adjuvant radiation in patients with nonmetastatic prostate cancer with high-risk pathologic features
Cancer. 2014 Oct 1;120(19) :3089-96
PMID: 24917426    PMCID: PMC4277873    URL: https://www.ncbi.nlm.nih.gov/pubmed/24917426
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BACKGROUND: The 2013 American Urological Association/American Society for Radiation Oncology consensus guidelines recommend offering adjuvant radiotherapy (RT) after radical prostatectomy in patients with high-risk pathologic features for recurrence. In the current study, the authors examined practice patterns of adjuvant RT use in patients with elevated pathologic risk factors over a time period spanning the publication of supporting randomized evidence. METHODS: Using the National Cancer Data Base, a total of 130,681 patients were identified who underwent surgical resection for prostate cancer between 2004 and 2011 with at least 1 of the following pathologic risk factors for early biochemical failure: pT3a disease or higher, positive surgical margins and/or lymph node-positive disease. Using multivariable logistic regression, the authors examined factors associated with adjuvant RT use including patient, clinical, demographic, and temporal characteristics. RESULTS: Adjuvant RT was administered to 9.9% of the patients with at least 1 pathologic risk factor. Use of adjuvant RT did not change over the study period (P = .23). On multivariable analysis, we found that patients treated at high-volume surgical facilities were less likely to receive adjuvant RT (15.9% vs 7.8%; odds ratio, 0.58 [95% confidence interval, 0.50-0.65]; P < .0001). Older age, comorbidities, black race, lower income, and lower population density were also associated with lower rates of adjuvant RT. CONCLUSIONS: Use of adjuvant RT is uncommon and remained unchanged between 2004 and 2011. Patients treated at high-volume surgical facilities are less likely to receive adjuvant RT, irrespective of margin status.
Kalbasi, Anusha Swisher-McClure, Samuel Mitra, Nandita Sunderland, Robert Smaldone, Marc C Uzzo, Robert G Bekelman, Justin E eng K07 CA163616/CA/NCI NIH HHS/ K07-CA163616/CA/NCI NIH HHS/ Observational Study Research Support, N.I.H., Extramural Cancer. 2014 Oct 1;120(19):3089-96. doi: 10.1002/cncr.28856. Epub 2014 Jun 10.