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Fahl SP , Coffey F , Wiest DL
Origins of gammadelta T Cell Effector Subsets: A Riddle Wrapped in an Enigma
J Immunol. 2014 Nov 1;193(9) :4289-4294
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Abstract
alphabeta and gammadelta T cells are thought to arise from a common precursor in the thymus but play distinct roles in pathogen resistance. Although conventional alphabeta T cells exit the thymus in a naive state and acquire effector function in the periphery, the effector fate of many gammadelta T cells is specified in the thymus and exhibits limited plasticity thereafter. This review describes the current models that have been proposed to explain the acquisition of effector fate by gammadelta T cells, as well as the apparent linkage to Vgamma gene usage. The two predominant models are the predetermination model, which suggests that effector fate is determined prior to TCR expression, perhaps in association with the developmental timing of Vgamma rearrangement, and the TCR-dependence model, which proposes that the nature of the TCR signal, particularly its intensity or duration, plays an important role in influencing effector fate.
Notes
1550-6606 Fahl, Shawn P Coffey, Francis Wiest, David L Review J Immunol. 2014 Nov 1;193(9):4289-4294.