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Nikonova AS , Gaponova AV , Kudinov AE , Golemis EA
CAS proteins in health and disease: an update
IUBMB Life. 2014 Jun;66(6) :387-95
PMID: 24962474 PMCID: PMC4111207 URL: https://www.ncbi.nlm.nih.gov/pubmed/24962474
AbstractThe CAS family of scaffolding proteins has increasingly attracted scrutiny as important for regulation of cancer-associated signaling. BCAR1 (also known as p130Cas), NEDD9 (HEF1, Cas-L), EFS (Sin), and CASS4 (HEPL) are regulated by and mediate cell attachment, growth factor, and chemokine signaling. Altered expression and activity of CAS proteins are now known to promote metastasis and drug resistance in cancer, influence normal development, and contribute to the pathogenesis of heart and pulmonary disease. In this article, we provide an update on recently published studies describing signals regulating and regulated by CAS proteins, and evidence for biological activity of CAS proteins in normal development, cancer, and other pathological conditions.
NotesNikonova, Anna S Gaponova, Anna V Kudinov, Alexander E Golemis, Erica A eng R01 CA63366/CA/NCI NIH HHS/ CA06927/CA/NCI NIH HHS/ U54 CA149147/CA/NCI NIH HHS/ R01 CA063366/CA/NCI NIH HHS/ P50 CA083638/CA/NCI NIH HHS/ P30 CA006927/CA/NCI NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review England IUBMB Life. 2014 Jun;66(6):387-95. doi: 10.1002/iub.1282. Epub 2014 Jun 24.