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Miller SM , Roussi P , Daly MB , Scarpato J
New strategies in ovarian cancer: uptake and experience of women at high risk of ovarian cancer who are considering risk-reducing salpingo-oophorectomy
Clin Cancer Res. 2010 Nov 1;16(21) :5094-106
PMID: 20829330   
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Here, we review factors associated with uptake of risk-reducing salpingo-oophorectomy by women at increased hereditary risk for ovarian cancer, as well as quality of life issues following surgery. Forty-one research studies identified through PubMed and PsychInfo met inclusion criteria. Older age, having had children, a family history of ovarian cancer, a personal history of breast cancer, prophylactic mastectomy, and BRCA1/2 mutation carrier status increase the likelihood of undergoing surgery. Psychosocial variables predictive of surgery uptake include greater perceived risk of ovarian cancer and cancer-related anxiety. Most women report satisfaction with their decision to undergo surgery and both lower perceived ovarian cancer risk and less cancer-related anxiety as benefits. Hormonal deprivation is the main disadvantage reported, particularly by premenopausal women who are not on hormonal replacement therapy (HRT). The evidence is mixed about satisfaction with the level of information provided prior to surgery, although generally, women report receiving insufficient information about the pros and cons of HRT. These findings indicate that when designing decision aids, demographic, medical history, and psychosocial variables need to be addressed in order to facilitate quality decision making.
Miller, Suzanne M Roussi, Pagona Daly, Mary B Scarpato, John P01CA57586/CA/NCI NIH HHS/United States P30 CA006927/CA/NCI NIH HHS/United States P30 CA006927-45/CA/NCI NIH HHS/United States R01 CA104979/CA/NCI NIH HHS/United States R01 CA104979-05/CA/NCI NIH HHS/United States R01 HG011766/HG/NHGRI NIH HHS/United States RC1 CA 145063-01/CA/NCI NIH HHS/United States RC1 CA145063-01/CA/NCI NIH HHS/United States Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Review United States Clin Cancer Res. 2010 Nov 1;16(21):5094-106. doi: 10.1158/1078-0432.CCR-09-2953. Epub 2010 Sep 9.