This is an archive of papers published by the staff and faculty of Fox Chase Cancer Center. For questions about content, please contact Talbot Research Library
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Seeger-Nukpezah T , Little JL , Serzhanova V , Golemis EA
Cilia and cilia-associated proteins in cancer
Drug Discov Today Dis Mech. 2013 Dec 1;10(3-4) :e135-e142
AbstractThe primary cilium is a well-established target in the pathogenesis of numerous developmental and chronic disorders, and more recently is attracting interest as a structure relevant to cancer. Here we discuss mechanisms by which changes in cilia can contribute to the formation and growth of tumors. We emphasize the cancer-relevance of cilia-dependent signaling pathways and proteins including mTOR, VHL, TSC, WNT, Aurora-A, NEDD9, and Hedgehog, and highlight the emerging role of ciliary dysfunction in renal cell carcinoma, medulloblastoma, and breast cancer.
NotesSeeger-Nukpezah, Tamina Little, Joy L Serzhanova, Victoria Golemis, Erica A R01 CA063366/CA/NCI NIH HHS/United States Journal article Drug Discov Today Dis Mech. 2013 Dec 1;10(3-4):e135-e142.