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Fang CY , Ross EA , Pathak HB , Godwin AK , Tseng M
Acculturative stress and inflammation among Chinese immigrant women
Psychosom Med. 2014 Jun;76(5) :320-6
PMID: 24846001 PMCID: PMC4164056 URL: https://www.ncbi.nlm.nih.gov/pubmed/24846001
AbstractOBJECTIVE: Among Chinese immigrant populations, increasing duration of US residence is associated with elevated risk for various chronic diseases. Although life-style changes after migration have been extensively studied in immigrant populations, the psychosocial impact of acculturative stress on biological markers of health is less understood. Thus, the purpose of the present study is to examine associations between acculturative stress and inflammatory markers in a Chinese immigrant population. METHODS: Study participants (n = 407 foreign-born Chinese American women) completed questionnaires assessing levels of stress, including acculturative stress and positive and negative life events in the previous year. Participant height and weight were measured using standard protocols, and blood samples were drawn for assessment of circulating serum levels of C-reactive protein (CRP) and soluble tumor necrosis factor receptor 2 (sTNFR2). RESULTS: Higher levels of acculturative stress were significantly associated with higher levels of CRP (B = 0.07, 95% confidence interval = 0.01-0.13, p = .031) and sTNFR2 (B = 0.02, 95% confidence interval = 0.004-0.03, p = .012), adjusting for age and body mass index. The latter association was no longer statistically significant when overall acculturation (i.e., identification with American culture) was included in the model. Life events were not associated with CRP or sTNFR2. CONCLUSIONS: This is one of the first studies to demonstrate that acculturative stress is associated with inflammatory markers in a Chinese immigrant population. Replication in other immigrant samples is needed to fully establish the biological correlates and clinical consequences of acculturative stress.
NotesFang, Carolyn Y Ross, Eric A Pathak, Harsh B Godwin, Andrew K Tseng, Marilyn eng K12 HD052027/HD/NICHD NIH HHS/ P30 CA006927/CA/NCI NIH HHS/ R01 CA106606/CA/NCI NIH HHS/ 3R01CA106606-05S1/CA/NCI NIH HHS/ Research Support, N.I.H., Extramural Psychosom Med. 2014 Jun;76(5):320-6. doi: 10.1097/PSY.0000000000000065.