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Hakanson M , Cukierman E , Charnley M
Miniaturized pre-clinical cancer models as research and diagnostic tools
Adv Drug Deliv Rev. 2014 Apr;69-70 :52-66
PMID: 24295904 PMCID: PMC4019677 URL: https://www.ncbi.nlm.nih.gov/pubmed/24295904
AbstractCancer is one of the most common causes of death worldwide. Consequently, important resources are directed towards bettering treatments and outcomes. Cancer is difficult to treat due to its heterogeneity, plasticity and frequent drug resistance. New treatment strategies should strive for personalized approaches. These should target neoplastic and/or activated microenvironmental heterogeneity and plasticity without triggering resistance and spare host cells. In this review, the putative use of increasingly physiologically relevant microfabricated cell-culturing systems intended for drug development is discussed. There are two main reasons for the use of miniaturized systems. First, scaling down model size allows for high control of microenvironmental cues enabling more predictive outcomes. Second, miniaturization reduces reagent consumption, thus facilitating combinatorial approaches with little effort and enables the application of scarce materials, such as patient-derived samples. This review aims to give an overview of the state-of-the-art of such systems while predicting their application in cancer drug development.
NotesHakanson, Maria Cukierman, Edna Charnley, Mirren eng P30 CA006927/CA/NCI NIH HHS/ R01 CA113451/CA/NCI NIH HHS/ CA06927/CA/NCI NIH HHS/ CA113451/CA/NCI NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review Netherlands Adv Drug Deliv Rev. 2014 Apr;69-70:52-66. doi: 10.1016/j.addr.2013.11.010. Epub 2013 Dec 1.