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Kelly ML , Astsaturov A , Chernoff J
Role of p21-activated kinases in cardiovascular development and function
Cellular and Molecular Life Sciences. 2013 Nov;70(22) :4223-4228
PMID: WOS:000326052900003 PMCID: PMC 3775977
Abstractp21-activated kinases (Paks) are a group of six serine/threonine kinases (Pak1-6) that are involved in a variety of biological processes. Recently, Paks, more specifically Pak1, -2, and -4, have been shown to play important roles in cardiovascular development and function in a range of model organisms including zebrafish and mice. These functions include proper morphogenesis and conductance of the heart, cardiac contractility, and development and integrity of the vasculature. The mechanisms underlying these effects are not fully known, but they likely differ among the various Pak isoforms and include both kinase-dependent and -independent functions. In this review, we discuss aspects of Pak function relevant to cardiovascular biology as well as potential therapeutic implications of small-molecule Pak inhibitors in cardiovascular disease.
NotesKelly, Mollie L. Astsaturov, Artyom Chernoff, Jonathan