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Developmental disease and cancer: Biological and clinical overlaps
Am J Med Genet A. 2013 Nov;161(11) :2788-96
AbstractNumerous parallelisms exist between development and cancer. In this article, I review some of the founding ideas linking development and cancer, and highlight clinical conditions exhibiting features of both developmental derangement and cancer predisposition, including cohesinopathies, rasopathies, phakomatoses, Proteus syndrome and other overgrowth disorders, recessive chromosome breakage syndromes, and dominant hereditary cancer syndromes. I suggest that these disorders encompass a continuous spectrum spanning clinical genetics and clinical oncology, and derive some general implications that might be useful in the future for the treatment of these diseases. (c) 2013 Wiley Periodicals, Inc.
NotesBellacosa, Alfonso United States American journal of medical genetics. Part A Am J Med Genet A. 2013 Nov;161(11):2788-96. doi: 10.1002/ajmg.a.36267. Epub 2013 Oct 7.