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Shafer D , Smith MR , Borghaei H , Millenson MM , Li T , Litwin S , Anad R , Al-Saleem T
Low NK cell counts in peripheral blood are associated with inferior overall survival in patients with follicular lymphoma
Leuk Res. 2013 Oct;37(10) :1213-5
PMID: 23968916   
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Host immune responses influence follicular lymphoma (FL) outcomes. To test our hypothesis that immune cells in blood reflect that response, we assessed by peripheral blood flow cytometry in 75 untreated FL patients the absolute counts of: lymphocytes (ALC), CD4(+)T (ACD4C), CD8(+)T (ACD8C) and natural killer (ANKC) cells. Low ANKC was the only parameter associated with inferior overall survival by univariate analysis (p=0.02), and trended to significance in multivariable analysis with ACD4C (p=0.08). Five (24%) patients with low initial ANKC died, while one (2%) with normal/high ANKC has died. In conclusion, evaluation of blood ANKC may be a useful indicator of outcome in previously untreated FL patients.
Shafer, Danielle Smith, Mitchell R Borghaei, Hossein Millenson, Michael M Li, Tianyu Litwin, Samuel Anad, Rachna Al-Saleem, Tahseen P30 CA006927/CA/NCI NIH HHS/United States England Leukemia research Leuk Res. 2013 Oct;37(10):1213-5. doi: 10.1016/j.leukres.2013.07.038. Epub 2013 Aug 7.