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Chen P , Balachandran S
Development of interferon gamma-based immunocytokines targeting renal cancer
Oncoimmunology. 2013 Jul 1;2(7) :e24964
AbstractAdvanced renal cancer is an incurable malignancy in need of novel therapeutic avenues. We have generated interferon gamma (IFNgamma)-based fusion antibodies (immunocytokines) that target CD70, a putative biomarker of renal cancer. These immunocytokines efficiently labeled renal cancer cells, and, when combined with the proteasome inhibitor bortezomib, killed them by activating a RIP1-dependent necrotic pathway.
NotesChen, Peirong Balachandran, Siddharth Oncoimmunology Oncoimmunology. 2013 Jul 1;2(7):e24964. Epub 2013 May 16.