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Ji Y , Tulin AV
Post-Transcriptional Regulation by Poly(ADP-ribosyl)ation of the RNA-Binding Proteins
Int J Mol Sci. 2013 ;14(8) :16168-83
PMID: 23921685 PMCID: PMC 3759905
AbstractGene expression is intricately regulated at the post-transcriptional level by RNA-binding proteins (RBPs) via their interactions with pre-messenger RNA (pre-mRNA) and mRNA during development. However, very little is known about the mechanism regulating RBP activities in RNA metabolism. During the past few years, a large body of evidence has suggested that many RBPs, such as heterogeneous nuclear ribonucleoproteins (hnRNPs), undergo post-translational modification through poly(ADP-ribosyl)ation to modulate RNA processing, including splicing, polyadenylation, translation, miRNA biogenesis and rRNA processing. Accordingly, RBP poly(ADP-ribosyl)ation has been shown to be involved in stress responses, stem cell differentiation and retinal morphogenesis. Here, we summarize recent advances in understanding the biological roles of RBP poly(ADP-ribosyl)ation, as controlled by Poly(ADP-ribose) Polymerases (PARPs) and Poly(ADP-ribose) Glycohydrolase (PARG). In addition, we discuss the potential of PARP and PARG inhibitors for the treatment of RBP-related human diseases, including cancer and neurodegenerative disorders.
NotesJi, Yingbiao Tulin, Alexei V Switzerland International journal of molecular sciences Int J Mol Sci. 2013 Aug 5;14(8):16168-83. doi: 10.3390/ijms140816168.