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Azadarmaki R , Lango MN
Malignant transformation of respiratory papillomatosis in a solid-organ transplant patient: case report and literature review
Ann Otol Rhinol Laryngol. 2013 Jul;122(7) :457-60
PMID: 23951698   
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Abstract
We report the case of a 77-year-old non-smoker and non-drinker with a solid-organ transplant who had malignant transformation of respiratory papillomatosis 3 years after the initial diagnosis of this benign lesion. This is the first case reported in the literature of malignant transformation of respiratory papillomatosis in a solid-organ transplant patient. Virus-associated cutaneous cancers occur more frequently and aggressively in solid-organ transplant patients. There may be a higher rate of malignant transformation of respiratory papillomatosis in immunosuppressed patients, as this is a virus-associated disease. Closer observation, airway evaluation with laryngoscopy and tracheobronchoscopy, and interval biopsies of immunosuppressed patients with respiratory papillomatosis is recommended.
Notes
Azadarmaki, Roya Lango, Miriam N United States The Annals of otology, rhinology, and laryngology Ann Otol Rhinol Laryngol. 2013 Jul;122(7):457-60.