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Gordiev Marat , Engstrom Paul F , Khasanov Rustem , Moroshek Anton , Sitdikov Rustem , Dgavoronkov Vladamir , Schnoll Robert A
Genetic analysis of polymorphisms in dopamine receptor and transporter genes for association with smoking among cancer patients
European Addiction Research. 2013 Feb;19(2) :105-111
PMID: Peer Reviewed Journal: 2013-14569-007    PMCID: PMC 3649069    URL: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=psyc7&AN=2013-14569-007
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Abstract
Background: Smoking among Russian cancer patients may be related to variations in the DRD2/ANKK1 (Taq1), DRD4 (exon III VNTR), and SLC6A3 genes. Methods: Seven hundred fifty patients provided smoking history and DNA. Results: Current smokers were more likely to be DRD2 A2 allele carriers versus nonsmokers (former/never smokers; 69 vs. 56%; OR = 1.69; 95% CI 1.13-2.53, p = 0.01) and former smokers (69 vs. 59%; OR = 1.54; 95% CI 0.97-2.46, p = 0.07). Ever smokers (current/former smokers) were more likely to be DRD2 A2 allele carriers versus never smokers (65 vs. 55%; OR = 1.50; 95% CI 1.00-2.27, p = 0.05). The risk of current smoking among DRD2 A2 allele carriers was present if the DRD4 short allele was also present (OR = 1.76; 95% CI 1.12-2.78, p = 0.02), and the risk of ever smoking among DRD2 A2 allele carriers was present if the DRD4 short allele was also present (OR = 1.62; 95% CI 1.02-2.55, p = 0.04). DRD2 A2 allele carriers had a shorter period of previous abstinence versus DRD2 A1 carriers (p = 0.02). Effects were not statistically significant when controlling for multiple comparisons. Conclusions: The DRD2 A2 allele may increase the risk of smoking among cancer patients, convergent with studies using non-Western samples. However, additional replication is needed. (PsycINFO Database Record (c) 2013 APA, all rights reserved) (journal abstract).
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