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Heckman CJ , Chandler R , Kloss JD , Benson A , Rooney D , Munshi T , Darlow SD , Perlis C , Manne SL , Oslin DW
Minimal Erythema Dose (MED) Testing
J Vis Exp. 2013 :e50175
PMID: 23748556    PMCID: PMC3734971    URL: http://www.ncbi.nlm.nih.gov/pubmed/23748556
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Ultraviolet radiation (UV) therapy is sometimes used as a treatment for various common skin conditions, including psoriasis, acne, and eczema. The dosage of UV light is prescribed according to an individual's skin sensitivity. Thus, to establish the proper dosage of UV light to administer to a patient, the patient is sometimes screened to determine a minimal erythema dose (MED), which is the amount of UV radiation that will produce minimal erythema (sunburn or redness caused by engorgement of capillaries) of an individual's skin within a few hours following exposure. This article describes how to conduct minimal erythema dose (MED) testing. There is currently no easy way to determine an appropriate UV dose for clinical or research purposes without conducting formal MED testing, requiring observation hours after testing, or informal trial and error testing with the risks of under- or over-dosing. However, some alternative methods are discussed.
Heckman, Carolyn J Chandler, Rachel Kloss, Jacqueline D Benson, Amy Rooney, Deborah Munshi, Teja Darlow, Susan D Perlis, Clifford Manne, Sharon L Oslin, David W United States Journal of visualized experiments : JoVE J Vis Exp. 2013 May 28;(75). doi: 10.3791/50175.