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Remakus S , Sigal LJ
Memory CD8(+) T cell protection
Adv Exp Med Biol. 2013 ;785 :77-86
AbstractMemory CD8 T cells play an essential role in controlling pathogenic infections. Therefore generating protective memory CD8 T cells by vaccination is an attractive strategy for preventing and treating a variety of human diseases. Understanding what comprises a protective memory CD8 T cell response will help optimize vaccine-induced CD8 T cell immunity. Here we discuss essential antiviral effector functions and highlight how recall expansion of memory CD8 T cells may affect the primary response.
NotesRemakus, Sanda Sigal, Luis J United States Advances in experimental medicine and biology Adv Exp Med Biol. 2013;785:77-86. doi: 10.1007/978-1-4614-6217-0_9.