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Nikonova AS , Astsaturov I , Serebriiskii IG , Dunbrack RL , Golemis EA
Aurora A kinase (AURKA) in normal and pathological cell division
Cellular and Molecular Life Sciences. 2013 Feb;70(4) :661-687
PMID: WOS:000314044900005 PMCID: PMC3607959
AbstractTemporally and spatially controlled activation of the Aurora A kinase (AURKA) regulates centrosome maturation, entry into mitosis, formation and function of the bipolar spindle, and cytokinesis. Genetic amplification and mRNA and protein overexpression of Aurora A are common in many types of solid tumor, and associated with aneuploidy, supernumerary centrosomes, defective mitotic spindles, and resistance to apoptosis. These properties have led Aurora A to be considered a high-value target for development of cancer therapeutics, with multiple agents currently in early-phase clinical trials. More recently, identification of additional, non-mitotic functions and means of activation of Aurora A during interphase neurite elongation and ciliary resorption have significantly expanded our understanding of its function, and may offer insights into the clinical performance of Aurora A inhibitors. Here we review the mitotic and non-mitotic functions of Aurora A, discuss Aurora A regulation in the context of protein structural information, and evaluate progress in understanding and inhibiting Aurora A in cancer.
NotesTimes Cited: 0 Nikonova, Anna S. Astsaturov, Igor Serebriiskii, Ilya G. Dunbrack, Roland L., Jr. Golemis, Erica A.