FCCC LOGO Faculty Publications
Klayton T , Price R , Buyyounouski MK , Sobczak M , Greenberg R , Li JS , Keller L , Sopka D , Kutikov A , Horwitz EM
Prostate Bed Motion During Intensity-Modulated Radiotherapy Treatment
International Journal of Radiation Oncology Biology Physics. 2012 Sep;84(1) :130-136
PMID: WOS:000308061900045    PMCID: PMC3285397   
Back to previous list
Purpose: Conformal radiation therapy in the postprostatectomy setting requires accurate setup and localization of the prostatic fossa. In this series, we report prostate bed localization and motion characteristics, using data collected from implanted radiofrequency transponders. Methods and Materials: The Calypso four-dimensional localization system uses three implanted radiofrequency transponders for daily target localization and real-time tracking throughout a course of radiation therapy. We reviewed the localization and tracking reports for 20 patients who received ultrasonography-guided placement of Calypso transponders within the prostate bed prior to a course of intensity-modulated radiation therapy at Fox Chase Cancer Center. Results: At localization, prostate bed displacement relative to bony anatomy exceeded 5 mm in 9% of fractions in the anterior-posterior (A-P) direction and 21% of fractions in the superior-inferior (S-I) direction. The three-dimensional vector length from skin marks to Calypso alignment exceeded 1 cm in 24% of all 652 fractions with available setup data. During treatment, the target exceeded the 5-mm tracking limit for at least 30 sec in 11% of all fractions, generally in the A-P or S-I direction. In the A-P direction, target motion was twice as likely to move posteriorly, toward the rectum, than anteriorly. Fifteen percent of all treatments were interrupted for repositioning, and 70% of patients were repositioned at least once during their treatment course. Conclusion: Set-up errors and motion of the prostatic fossa during radiotherapy are nontrivial, leading to potential undertreatment of target and excess normal tissue toxicity if not taken into account during treatment planning. Localization and real-time tracking of the prostate bed via implanted Calypso transponders can be used to improve the accuracy of plan delivery. (C) 2012 Elsevier Inc.
Klayton, Tracy Price, Robert Buyyounouski, Mark K. Sobczak, Mark Greenberg, Richard Li, Jinsheng Keller, Lanea Sopka, Dennis Kutikov, Alexander Horwitz, Eric M. National Cancer Institute, NIH[P30 CA006927] This publication was supported by grant number P30 CA006927 from the National Cancer Institute, NIH. Its contents are solely the responsibility of the authors and does not necessarily represent the official views of the National Cancer Institute or the National Institutes of Health. 20 Elsevier science inc New york 996co