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Cukierman E , Bassi DE
The mesenchymal tumor microenvironment A drug-resistant niche
Cell Adhesion & Migration. 2012 May-Jun;6(3) :285-296
PMID: WOS:000307868700017 PMCID: PMC3427243
AbstractDrug and radiation resistance represent a challenge for most anticancer therapies. Diverse experimental approaches have provided evidence that the tumor-associated microenvironment constitutes both a protective shell that impedes drug or radiation access and a permissive or promotive microenvironment that encourages a nurturing cancer (i.e., cancer stem cell) niche where tumor cells overcome treatment-and cancer-induced stresses. Better understanding of the effects of the tumor microenvironment on cancer cells before, during and immediately after chemo-or radiotherapy is imperative to design new therapies aimed at targeting this tumor-protective niche. This review summarizes some of the known mesenchymal stromal effects that account for drug resistance, the main signal transduction pathways associated with this resistance and the therapeutic efforts directed to increase the success of current therapies. Special emphasis is given to environment-mediated drug resistance in general and to cell adhesion-mediated drug resistance in particular.
NotesCukierman, Edna Bassi, Daniel E. NIH/NCI[CA113451]; Keystone Program in Personalized Kidney Cancer Therapy at Fox Chase Cancer Center We would like to thank Drs A. Klein-Szanto, A. O'Reilly for discussions, G. Hudes for consultation and discussions, as well as E. Ragan for proofreading. This review was supported by NIH/NCI CA113451 and by The Keystone Program in Personalized Kidney Cancer Therapy at Fox Chase Cancer Center. 161 Landes bioscience Austin 993oj Llamy wt, 1991, cancer research, v51, p995