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Velvadapu V , McDonnell ME , Jaffe EK , Reitz AB
Facile synthesis of mutagen X (MX): 3-chloro-4-(dichloromethyl)-5-hydroxy-5H-furan-2-one
Tetrahedron Letters. 2012 Jun;53(25) :3144-3146
PMID: WOS:000304798600008    PMCID: PMC3398704   
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Abstract
3-Chloro-4-(dichloromethyl)-5-hydroxy-5H-furan-2-one (mutagen X, MX) was synthesized in six steps from commercially-available and inexpensive starting materials (27% overall yield). This synthesis enables the preparation of MX analogs and does not require the use of chlorine gas, as do previously reported methods. (C) 2012 Elsevier Ltd. All rights reserved.
Notes
Velvadapu, Venkata McDonnell, Mark E. Jaffe, Eileen K. Reitz, Allen B. National Institutes of Health[1 R43 AI084224-01] The authors would like to thank Dr. Jeff Pelletier for helpful discussions. We also acknowledge the support of the National Institutes of Health (1 R43 AI084224-01). 32 Pergamon-elsevier science ltd Oxford 952ng Rihata c, 1992, water science and technology, v25, p341