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Lubbe W , Cohen R , Sharma N , Ruth K , Peters R , Li JS , Buyyounouski M , Kutikov A , Chen D , Uzzo R , Horwitz E
Biochemical and clinical experience with real-time intraoperatively planned permanent prostate brachytherapy
Brachytherapy. 2012 May-Jun;11(3) :209-213
PMID: WOS:000303291600007   
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PURPOSE: To evaluate patient characteristics and dosimetric parameters that predict biochemical failure (BCF) after real-time planned low-dose-rate prostate brachytherapy. METHODS: From 1998 to 2008, a low-risk cohort by National Comprehensive Cancer Network criteria of 341 men with a median followup of 41.6 months was analyzed. This cohort had a median age of 65.1 years, prostate volume of 35.8 cc, and pretreatment prostate-specific antigen of 5.6 ng/mL. Patients had predominately Gleason 6 (95.9%) and T1c (81.3%) disease. About 3.6% of the patients received androgen deprivation therapy. Kaplan-Meier and Cox proportional hazards survival analysis methods were used to analyze predictors of BCF (Phoenix definition). RESULTS: At 72 months, freedom from BCF was 91.1% (95% confidence interval = 85.0-94.8). The median D-90 was 145.9 Gy, and the median V-100 was 90.3%. Because of infrequent BCF, the following prostate volume groups were examined: 15-<25, 25-<35, 35-<45, and 45+ cc. Of all possible predictors, only small prostate volume (15-<25 cc group) was significantly associated with BCF (hazard ratio = 8.44,95% confidence interval = 1.82-39.14, p = 0.007). Using Kaplan-Meier analysis, time to BCF was also significantly increased in the lowest prostate volume 15-<25 cc group with 24.1% failing at 48 months compared with 1.6-5.1% among the other groups. CONCLUSIONS: Real-time planned low-dose-rate prostate brachytherapy provides excellent biochemical control as a single-agent treatment for low-risk prostate cancer with 91.1% freedom from BCF at 72 months. Only prostate volume less than 25 cc was an independent predictor of BCF. (C) 2012 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.
Lubbe, Wilhelm Cohen, Randi Sharma, Navesh Ruth, Karen Peters, Ruth Li, Jinsheng Buyyounouski, Mark Kutikov, Alexander Chen, David Uzzo, Robert Horwitz, Eric 26 Elsevier science inc New york 932lc