FCCC LOGO Faculty Publications
Shields CL , Hogarty MD , Kligman BE , Christian C , Ehya H , Shields JA
Langerhans cell histiocytosis of the uvea with neovascular glaucoma: Diagnosis by fine-needle aspiration biopsy and management with intraocular bevacizumab and brachytherapy
Journal of Aapos. 2010 Dec;14(6) :534-537
PMID: ISI:000285673900017   
Back to previous list
A 6-year-old boy with known multisystem Langerhans cell histiocytosis developed photophobia, conjunctival injection, iris neovascularization, and an iridociliochoroidal mass. Fine-needle aspiration biopsy revealed mononucleated and multinucleate histiocytes that demonstrated positive immunostaining for CD68 and 8100 consistent with Langerhans cell histiocytosis. Management with intracameral bevacizumab (1.25 mg/0.05 ml) resolved the iris neovascularization, and plaque radiotherapy (brachytherapy) resolved the mass rapidly and completely, preserving the patient's visual acuity and preventing glaucoma during the 10-month follow-up.
Shields, Carol L. Hogarty, Michael D. Kligman, Brad E. Christian, Colleen Ehya, Hormoz Shields, Jerry A. Eye Tumor Research Foundation, Philadelphia, PA Support provided by the Eye Tumor Research Foundation, Philadelphia, PA (CLS). The funders had no role in the design and conduct of the study, in the collection, analysis, and interpreration of the data, and in the preparation, review or approval of the manuscript. Carol L. Shields, MD, has had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. 21 Mosby-elsevier; 360 park avenue south, new york, ny 10010-1710 usa 699oy