FCCC LOGO Faculty Publications
Roach M , Bae K , Lawton C , Donnelly BJ , Grignon D , Hanks GE , Porter A , Lepor H , Venketesan V , Sandler H
BASELINE SERUM TESTOSTERONE IN MEN TREATED WITH ANDROGEN DEPRIVATION THERAPY AND RADIOTHERAPY FOR LOCALIZED PROSTATE CANCER
International Journal of Radiation Oncology Biology Physics. 2010 Dec;78(5) :1314-1322
PMID: ISI:000284987800004   
Back to previous list
Abstract
Introduction It is believed that men diagnosed with prostate cancer and a low baseline serum testosterone (BST) may have more aggressive disease, and it is frequently recommended they forgo testosterone replacement therapy We used two large Phase III trials involving androgen deprivation therapy and external beam radiation therapy to assess the significance of a BST Methods and Materials All patients with a BST and complete data (n = 2,478) were Included in this analysis and divided into four categories "Very Low BST" (VLBST) <= 16 5th percentile of BST (<= 248 ng/dL, n = 408), "Low BST" (LBST) >16 5th percentile and <= 33rd percentile (>248 ng/dL but <= 314 ng/dL, n = 415), "Average BST" (ABST) >33rd percentile and <= 67th percentile (314-437 ng/dL, n = 845), and "High BST" (HBST) >67th percentile (>437 ng/dL, n = 810) Outcomes included overall survival, distant metastasis, biochemical failure, and cause-specific survival All outcomes were adjusted for the following covariates treatment arm, BST, age (<70 vs >= 70), prostate specific antigen (PSA, <10 vs 10 <= PSA <20 vs 20 <=), Gleason score (2-6 vs 7 vs 8-10), T stage (T1 T2 vs T3 T4), and Karnofsky Performance Status (60-90 vs 100) Results On multivariable analysis age, Gleason score, and PSA were independently associated with an increased risk of biochemical failure, distant metastasis and a reduced cause specific and overall survival (p <0 05), but BST was not Conclusions BST does not affect outcomes in men treated with external beam radiation therapy and androgen deprivation therapy for prostate cancer (C) 2010 Elsevier Inc
Notes
Roach, Mack, III Bae, Kyounghwa Lawton, Colleen Donnelly, B. J. Grignon, David Hanks, Gerald E. Porter, Arthur Lepor, Herbert Venketesan, Varagur Sandler, Howard National Cancer Institute (NCI) [RTOG U10 CA21661, CCOP U10 CA37422, Stat U10 CA32115] Supported by RTOG U10 CA21661, CCOP U10 CA37422 and Stat U10 CA32115 grants from the National Cancer Institute (NCI) This manuscript s contents are the sole responsibility of the authors and do not necessarily represent the official views of the NCI The human investigations were performed after approval by a local Human Investigations Committee and in accordance with an assurance filed with and approved by the Department of Health and Human Services 38 Elsevier science inc; 360 park ave south, new york, ny 10010-1710 usa 690fl