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Doss M , Zhang JJ , Belanger MJ , Stubbs JB , Hostetler ED , Alpaugh K , Kolb HC , Yu JQ
Biodistribution and radiation dosimetry of the hypoxia marker 18F-HX4 in monkeys and humans determined by using whole-body PET/CT
Nucl Med Commun. 2010 Dec;31(12) :1016-24
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OBJECTIVES: F-HX4 is a novel positron emission tomography (PET) tracer for imaging hypoxia. The purpose of this study was to determine the biodistribution and estimate the radiation dose of F-HX4 using whole-body PET/computed tomography (CT) scans in monkeys and humans. METHODS: Successive whole-body PET/CT scans were done after the injection of F-HX4 in four healthy humans (422+/-142 MBq) and in three rhesus monkeys (189+/-3 MBq). Biodistribution was determined from PET images and organ doses were estimated using OLINDA/EXM software. RESULTS: The bladder, liver, and kidneys showed the highest percentage of the injected radioactivity for humans and monkeys. For humans, approximately 45% of the activity is eliminated by bladder voiding in 3.6 h, and for monkeys 60% is in the bladder content after 3 h. The critical organ is the urinary bladder wall with the highest absorbed radiation dose of 415+/-18 (monkeys) and 299+/-38 muGy/MBq (humans), in the 4.8-h bladder voiding interval model. The average value of effective dose for the adult male was estimated at 42+/-4.2 muSv/MBq from monkey data and 27+/-2 muSv/MBq from human data. CONCLUSION: Bladder, kidneys, and liver have the highest uptake of injected F-HX4 activity for both monkeys and humans. The urinary bladder wall receives the highest dose of F-HX4 and is the critical organ. Thus, patients should be encouraged to maintain adequate hydration and void frequently. The effective dose of F-HX4 is comparable with that of other F-based imaging agents.
Doss, Mohan Zhang, James J Belanger, Marie-Jose Stubbs, James B Hostetler, Eric D Alpaugh, Katherine Kolb, Hartmuth C Yu, Jian Q Research Support, Non-U.S. Gov't England Nuclear medicine communications Nucl Med Commun. 2010 Dec;31(12):1016-24.